New one-step method to make multiple edits to a cell’s genome
https://www.eurekalert.org/news-releases/1050844
By the GLADSTONE INSTITUTES
Gladstone Institutes scientists have developed a groundbreaking method to make multiple precise edits to a cell’s genome simultaneously using molecules called retrons. This innovation, detailed in a study published in Nature Chemical Biology, overcomes the limitations of traditional genome editing, which allows only one modification at a time. The new tool, called multitrons, can efficiently edit DNA in bacteria, yeast, and human cells, enabling applications in molecular recording and metabolic engineering. This advancement is a significant step towards understanding and treating complex genetic diseases.